GPCRs Structure, Function, and Drug Discovery

GPCRs Structure, Function, and Drug Discovery 2020 Original pdf

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AUTHORS: Beata Jastrzebska and Paul S.-H. Park

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GPCRs Structure, Function, and Drug Discovery 2020 Original pdf

GPCRS: Structure, Function, and Drug Discovery provides a comprehensive overview of recent discoveries and our current understanding of GPCR structure, signaling, physiology, pharmacology and methods of study. In addition to the fundamental aspects of GPCR function and dynamics, international experts discuss crystal structures, GPCR complexes with partner proteins, GPCR allosteric modulation, biased signaling through protein partners, deorphanization of GPCRs, and novel GPCR-targeting ligands that could lead to the development of new therapeutics against human diseases. GPCR association with, and possible therapeutic pathways for, retinal degenerative diseases, Alzheimer’s disease, Parkinson’s disease, cancer and diabetic nephropathy, among other illnesses, are examined in-depth.

AUTHORS: Beata Jastrzebska and Paul S.-H. Park

YEAR: 2020

PUBLICATION: Academic Press

LANGUAGE: English

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