Drug Selectivity: An Evolving Concept in Medicinal Chemistry (Methods and Principles in Medicinal Chemistry) ()

by Norbert Handler (Editor),‎ Helmut Buschmann (Series Editor),‎ Raimund Mannhold (Series Editor),‎ Jörg Holenz (Series Editor) & 1 more

With its wide-ranging view of an emerging new paradigm in drug development, “Multiple Ligand Approaches in Drug Design: Towards Selective Pharmacology” is an essential reference for medicinal and pharmaceutical chemists. The book not only provides insights into the theoretical aspects of multiple ligand approaches but also practical strategies and technologies that can be implemented in drug development. The case studies presented in the book demonstrate the effectiveness of the multiple ligand approach in various disease areas, further highlighting the potential of this approach in improving therapeutic outcomes.

One of the key advantages of the multiple ligand approach is the potential to overcome the limitations of traditional single-target drug development. By targeting multiple molecular targets, researchers can develop drugs that exhibit improved efficacy and reduced side effects. This approach is particularly promising for complex diseases where multiple molecular targets are involved.

The book delves into different design approaches that can be used to develop selective drugs. It explores the exploration of chemical space, which involves screening large libraries of compounds to identify molecules with desired properties. The design of multi-target-directed ligands is also discussed, which involves designing compounds that can interact with multiple targets simultaneously. Additionally, the book explores the merging of multiple ligands, where multiple compounds are merged into a single molecule to achieve selectivity.

Computational methods and high-throughput screening are valuable tools in the multiple ligand approach. These methods allow researchers to efficiently screen large libraries of compounds and predict their multi-target activity. The book discusses the use of these methods in drug discovery and provides examples of successful applications.

Furthermore, the book presents case studies from different disease areas to illustrate the potential of the multiple ligand approach. It showcases success stories in the development of selective drugs for cancer, neurodegenerative diseases, and infectious diseases. These case studies provide valuable insights into the practical application of the multiple ligand approach and highlight its potential for impacting patient care.

With its comprehensive coverage and practical insights, “Multiple Ligand Approaches in Drug Design: Towards Selective Pharmacology” is a valuable resource for medicinal and pharmaceutical chemists. The book offers an in-depth understanding of the theoretical and practical aspects of the multiple ligand approach, helping researchers stay at the forefront of drug development.

Order your copy of “Multiple Ligand Approaches in Drug Design: Towards Selective Pharmacology” today and explore the cutting-edge strategies and technologies in drug development. Join the global community of medicinal and pharmaceutical chemists who are embracing the multiple ligand approach to develop selective drugs with improved therapeutic outcomes. Start your journey towards advancing patient care and making a lasting impact in the field of medicinal chemistry.