The targeted therapy has revolutionized the medical treatment of malignant diseases in the last two decades. Unlike traditional chemotherapy, the successful use of such drugs is fundamentally dependent on the presence of specific target structures in cancer cells. Therefore, the accurate detection of these target structures through molecular testing plays a central role in targeted tumor treatment and is ultimately the basis of personalized oncology.

In line with its title, the present monograph summarizes the fundamentals and current aspects of modern HER2 diagnostics. This volume is not only aimed at pathologists and laboratory physicians but also at interested clinicians involved in the treatment of patients with HER2-positive tumors on a daily basis.

Authored by Christian M. Kurbacher, this book provides a comprehensive overview of the importance of molecular testing in targeted therapy and the specific case of HER2 diagnostics. It explores the fundamental concepts and technologies used to identify HER2-positive tumors and discusses their implications for personalized oncology.

The book starts by laying the groundwork for understanding targeted therapy and the significance of molecular testing in cancer treatment. It explains the mechanisms of action of targeted drugs and their advantages over traditional chemotherapy. The author emphasizes the importance of accurate HER2 diagnostics, as HER2-positive tumors are known to respond well to targeted treatment.

The subsequent chapters delve into the specific techniques and assays used to detect HER2 overexpression or amplification. The author highlights the role of immunohistochemistry and fluorescence in situ hybridization (FISH) in assessing HER2 status and defining the eligibility for HER2-targeted therapy. The reader is guided through the interpretation of test results and the challenges faced in determining HER2 status in different tumor types and scenarios.

The author also discusses the evolving field of HER2 testing, including the introduction of new molecular assays that have improved the accuracy and reproducibility of HER2 diagnostics. The book explores the emerging role of next-generation sequencing in HER2 testing and the integration of other biomarkers to refine treatment decisions.

Throughout the book, clinical cases and real-world examples are presented to illustrate the practical applications of HER2 diagnostics in the context of personalized oncology. The author shares insights from his vast experience in the field and provides recommendations for best practices in HER2 testing and interpretation of results.

Overall, “HER2-Diagnostik: Grundlagen und Aktuelle Aspekte” offers a comprehensive and up-to-date overview of the role of HER2 diagnostics in targeted tumor treatment. It provides valuable insights for pathologists, laboratory physicians, and clinicians involved in the care of patients with HER2-positive tumors. Moreover, it serves as a guide for understanding the importance of molecular testing in personalized oncology and its impact on treatment decisions.

Product Details

• ASIN: B09FRJFM4Z
• Publisher: UNI-MED Verlag AG; 1st edition (May 31, 2015)
• Publication date: May 31, 2015
• Language: German

Order your copy of “HER2-Diagnostik: Grundlagen und Aktuelle Aspekte” today and gain a deeper understanding of the role of HER2 diagnostics in personalized oncology. Discover the latest advancements in molecular testing and learn how to implement them in your clinical practice. Stay up to date with the evolving field of targeted therapy and improve the care you provide to patients with HER2-positive tumors.