Are you tired of suffering from chronic pain? Do you wish there was a safe and effective solution to relieve your discomfort? Look no further! We present to you the groundbreaking monograph, “Pain Receptors and Non-Opioid Analgesics: Molecular Mechanisms and Novel Targeting Approaches,” authored by Boris V. Krylov, Ilia V. Rogachevskii, Tatiana N. Shelykh, Vera B. Plakhova, and one more. This comprehensive study explores the molecular mechanisms of pain receptors and the development of a novel class of analgesics that could revolutionize the way we treat chronic pain.

The monograph delves deep into the methods used to study pain receptors, providing a summary of the latest research and experimental results. The authors focus on the molecular mechanisms of nociceptive information control in primary sensory nociceptive neurons, specifically the opioid-like receptor → Na+,K+-ATPase → NaV1.8 channel signaling cascade. Through their investigations, the authors have discovered two novel targeting mechanisms for modulating the NaV1.8 channels responsible for coding noxious signals.

The first targeting mechanism involves the activation of opioid-like receptors, while the second mechanism involves the activation of Na+,K+-ATPase as a signal transducer. Based on this groundbreaking data, the authors propose the development of a novel class of analgesics that trigger these mechanisms. These analgesics have the potential to provide effective and long-lasting relief from chronic pain, a problem that affects millions of people worldwide.

Throughout the monograph, the authors cover various topics, including the general methods used in studying nociceptive pain, such as the patch-clamp method. They also explore the mechanism behind the binding of different ligands to pain receptors, including gamma-pyrones, gamma-pyridines, and cardiotonic steroids.

This monograph is not only a valuable reference for neuroscientists and pharmacologists but also for allied researchers who are dedicated to the development of safe and effective analgesics. By understanding the molecular mechanisms of pain receptors, researchers can better target these receptors and develop analgesics that provide precise and targeted pain relief.

Imagine a world where chronic pain is no longer a burden. Thanks to the groundbreaking research presented in this monograph, that world could become a reality. By ordering “Pain Receptors and Non-Opioid Analgesics: Molecular Mechanisms and Novel Targeting Approaches,” you are taking a step towards a pain-free future. This monograph unravels the mysteries of pain receptors and provides insights into the development of potentially life-changing analgesics.

Don’t let chronic pain control your life any longer. Order your copy of “Pain Receptors and Non-Opioid Analgesics: Molecular Mechanisms and Novel Targeting Approaches” today and embark on a journey towards a pain-free future.

Book Details:

• Series: Frontiers in Pain Science (Book 1)
• ebook Digital: 211 pages
• Publisher: Bentham Science Publishers (August 3, 2017)
• Language: English
• ISBN-10: 1608059316
• ISBN-13: 978-1608059317
• Product Dimensions: 7 x 0.5 x 10 inches