Trials for Cerebellar Ataxias: From Cellular Models to Human Therapies (Contemporary Clinical Neuroscience)

By Bing-wen Soong, Mario Manto, Alexis Brice, Stefan M. Pulst
Despite the critical importance of the cerebellum in brain function, the scientific community still lacks effective treatments for most cerebellar ataxias.  This book provides  a link between the pathogenesis and therapies of cerebellar ataxias while also providing a comprehensive assessment of the preclinical and clinical trials dedicated to cerebellar ataxias over the past 20 years of progress.  This is the first book fully dedicated to the trials and therapies of these disorders. It is a truly authoritative and comprehensive reference, and comes at a time of major advances in genetic tools and neuroimaging assessments.  The coverage begins by laying a foundation of the basic science of the cerebellum and ataxias, proceeds to discuss biomarkers and the tools of trials, offers guidelines on conducting trials,  and then explores the full range of therapeutics and their trials, including gene therapy and cell transplantation. The authors are top experts on cerebellar research and the contributing authors have all made seminal contributions in the field.

The cerebellum is one of the most critical parts of the human brain that plays a vital role in maintaining a body’s motor and sensory functions. A disorder of this region can cause cerebellar ataxias, which are characterized by difficulties in coordination, balance, and speech. Despite extensive research, the scientific community still lacks effective treatments for most cerebellar ataxias. That’s where the new book, “Trials and Therapies for Cerebellar Ataxias,” comes in. It is a comprehensive and authoritative reference that highlights the pathogenesis and therapies of cerebellar ataxias and provides a detailed assessment of the preclinical and clinical trials dedicated to the field over the past 20 years of progress.

The book is written by a group of top experts on cerebellar research, including Bing-wen Soong, Mario Manto, Alexis Brice, and Stefan M. Pulst. The contributing authors have all made seminal contributions in the field and come from various academic and industry backgrounds. The coverage of the book is not limited to the basic science of the cerebellum and ataxias; it also includes discussions on biomarkers and the tools needed to conduct clinical trials. The book then explores a range of therapeutics and their trials, such as gene therapy and cell transplantation.

“Trials and Therapies for Cerebellar Ataxias” is the first book of its kind to offer such a comprehensive assessment of the trials and therapies of these disorders. It comes at a time of major advances in genetic tools and neuroimaging assessments. The book provides readers with guidelines on conducting trials and provides a comprehensive overview of the full range of therapeutic options available today.

The book begins with the foundation of the basic science of the cerebellum, including the anatomy, physiology, and immunology of the cerebellum. This foundational knowledge is then used to provide a comprehensive understanding of the pathogenesis of cerebellar ataxias. The book goes on to discuss clinical and preclinical trials and provides a detailed analysis of the various therapeutics used in these trials.

One of the most interesting aspects of the book is the discussion on gene therapy and cell transplantation. While these treatments hold enormous promise, they are still in the early stages of development. The book provides readers with a comprehensive overview of these treatments’ current status and their potential as future therapies.

In summary, “Trials and Therapies for Cerebellar Ataxias” is a must-read book for anyone interested in the latest scientific research on cerebellar ataxias. The authors provide an authoritative and comprehensive reference, which covers all aspects of the disorder science, including the pathogenesis and therapy of the condition. The book is highly informative and engaging, making it an excellent resource for researchers in the field and individuals who suffer from cerebellar ataxias or their caregivers. The digital version of the book spans 738 pages and is available in English.

Getting a copy of this book is like having a front-row seat in the world of cerebellar ataxias research. From its pages, readers stand to gain valuable insights and knowledge that can help them make informed decisions about their care or the care of their loved ones. The book presents a definitive guide to understanding cerebellar ataxias, which can help patients, caregivers, researchers, and healthcare professionals. So, if you’re passionate about neuroscience or have a professional interest in neurology, it’s time to order your copy of “Trials and Therapies for Cerebellar Ataxias” and be part of the journey to find effective treatments for cerebellar ataxias.

Product Details

• Publisher ‏ : ‎ Springer; 1st ed. 2023 edition (May 30, 2023)
• Language ‏ : ‎ English
• Hardcover ‏ : ‎ 738 pages
• ISBN-10 ‏ : ‎ 3031243447
• ISBN-13 ‏ : ‎ 978-3031243448