By Milka Kostic, Lyn H. Jones
Protein Homeostasis in Drug Discovery

Protein homeostasis is a fundamental process in all living organisms, ensuring that proteins are properly folded, localized, and maintained at the appropriate levels for cellular function. Disruption of protein homeostasis is implicated in numerous diseases, including cancer, neurodegenerative disorders, and cardiovascular conditions. Understanding and targeting protein homeostasis has become a prominent area of research in drug discovery, as it offers new opportunities for therapeutic intervention.

In their comprehensive book, Protein Homeostasis in Drug Discovery, authors Milka Kostic and Lyn H. Jones explore the multifaceted aspects of protein homeostasis, providing readers with a thorough understanding of the field. The book encompasses both historical perspectives on protein homeostasis and the latest technological advancements that are revolutionizing the way we approach drug discovery.

The authors begin by laying the foundation of protein homeostasis, discussing its importance in cellular processes such as folding, quality control, pharmacology, and drug targeting. They delve into the intricate mechanism of protein folding, highlighting the quality control mechanisms that ensure proteins achieve their correct conformation. This knowledge is crucial for drug development, as misfolded proteins have been linked to a variety of diseases.

As the book progresses, Kostic and Jones explore emerging technologies that enable researchers to study and manipulate protein homeostasis. They discuss methods for analyzing protein abundance, localization, interactions, and post-translational modifications, providing the reader with a comprehensive overview of the different regulatory events that control protein homeostasis. The authors also highlight the exciting field of targeted protein degradation (TPD), which involves the selective removal of disease-causing proteins through small molecules.

One of the key strengths of this book is its emphasis on real-world applications and drug discovery efforts targeting protein homeostasis. Kostic and Jones provide numerous examples of drug development strategies aimed at correcting, stabilizing, and rescuing proteins. They discuss the advantages and shortcomings of both phenotypic and target-based traditional drug discovery methods, highlighting the need for a comprehensive understanding of protein homeostasis to develop effective therapeutics.

Protein Homeostasis in Drug Discovery also explores recent developments in TPD, including the use of PROTACs and molecular glues, which have gained significant attention in the field. The authors dedicate an entire chapter to TPD as an antiviral drug discovery strategy, shedding light on the potential of these novel approaches in combating viral infections.

For readers interested in the link between biological function and protein homeostasis, this book provides a wealth of knowledge. Kostic and Jones outline the latest insights into the regulation of protein levels in living organisms and its implications for drug discovery. They highlight the interconnectedness of protein homeostasis with cellular processes, offering a nuanced perspective that goes beyond solely targeting protein activity.

The book is written in a clear and accessible style, making it suitable for a wide range of readers. Whether you are an academic researcher, a professional in the pharmaceutical industry, or an advanced student in science-related fields, Protein Homeostasis in Drug Discovery offers valuable insights into this rapidly evolving field.

Overall, Protein Homeostasis in Drug Discovery is a comprehensive resource that covers all aspects of protein homeostasis, providing readers with a deep understanding of the field. It not only serves as an authoritative guide for researchers but also sparks curiosity and promotes the exploration of protein homeostasis as a novel avenue for therapeutic interventions.

If you are interested in delving into the exciting world of protein homeostasis and its potential in drug discovery, I highly recommend ordering a copy of Protein Homeostasis in Drug Discovery today. With its wealth of knowledge, compelling examples, and comprehensive coverage, this book is a must-read for anyone interested in advancing their understanding of protein biology and its implications for developing innovative therapeutics. Order your copy now and embark on a journey into the fascinating realm of protein homeostasis!

Product Details

• Publisher ‏ : ‎ Wiley; 1st edition (December 8, 2022)
• Language ‏ : ‎ English
• eBook Digital ‏ : ‎ 560 pages
• ISBN-10 ‏ : ‎ 1119774128
• ISBN-13 ‏ : ‎ 978-1119774129