In this book, Dong Yu explores the applications of mRNA technology, with a particular focus on infectious diseases. The author also touches on other indications, such as immunotherapies and molecular therapies. The potent and long-lasting immune responses observed in animal models, along with encouraging data from early human clinical studies, support the use of mRNA-based vaccination as an attractive alternative to conventional vaccine approaches.

One of the highlights of this book is its coverage of the success of mRNA-based COVID-19 vaccines. With the global pandemic highlighting the need for fast and effective vaccine development, mRNA vaccines have emerged as a leading contender. The book discusses the development progress of the technology, including production, capabilities, and clinical development.

Aside from COVID-19, the author also addresses the broader potential of mRNA vaccines in combating other infectious diseases. The future of mRNA vaccines looks promising, thanks to their high potency, potential for low-cost manufacturing, and entirely synthetic nature. Furthermore, mRNA vaccines have the advantage of minimizing the time between pathogen identification and vaccine release, making a significant impact on public health.

As a comprehensive review series, this book covers everything from basic RNA biology and preclinical studies to manufacturing strategy, clinical development, and regulatory approval. It is an essential resource for established RNA researchers and developers, providing updates on the latest advancements in the field.