Welcome to the world of miRNA and cancer research! In the latest volume of Advances in Cancer Research, Volume 135, edited by Paul B Fisher, Carlo Croce, and Kenneth D Tew, you will find a treasure trove of information on the exciting and fast-moving field of cancer research. This volume presents original reviews on research bridging oncology and gene expression, with a specific focus on the role of microRNAs (miRNAs) in cancer.

miRNAs are small non-coding RNAs that play crucial roles in gene regulation. They have been found to be dysregulated in various types of cancer, and their aberrant expression is associated with tumor development, progression, and metastasis. This volume explores the enigma of miRNA regulation in cancer, shedding light on the intricate mechanisms by which these small molecules influence gene expression and cellular processes.

The book starts off with a chapter on non-coding RNAs as biomarkers of cancer. Biomarkers are molecules that can be detected in the body and used as indicators of disease presence or progression. The use of non-coding RNAs, particularly miRNAs, as biomarkers holds great potential for improving cancer diagnosis, prognosis, and treatment.

Next, the book delves into the various animal models that are used to study miRNA functions in cancer. Animal models are invaluable tools for understanding the complex interactions between miRNAs and cancer, and for testing potential therapeutic interventions.

One of the chapters in this volume focuses on the role of miRNAs in cancer susceptibility. Certain miRNAs have been implicated in the regulation of genes that are involved in DNA repair, cell cycle control, and apoptosis. Dysregulation of these miRNAs can lead to an increased risk of developing cancer. Understanding the molecular mechanisms behind cancer susceptibility can aid in the development of targeted prevention and treatment strategies.

The book also explores the fascinating world of ts-RNAs versus miRNAs. ts-RNAs, or transfer RNA-derived small RNAs, are a recently discovered class of small RNAs that have been found to have functions in gene regulation. This chapter discusses the similarities and differences between miRNAs and ts-RNAs, and their respective roles in cancer.

Another chapter focuses on miRNAs in acute myeloid leukemia (AML). AML is a type of cancer that affects the blood and bone marrow, and miRNAs have been found to be dysregulated in AML patients. Understanding the role of miRNAs in AML can provide insights into the pathogenesis of this disease and potentially lead to the development of targeted therapies.

The book also touches on the role of miRNAs in epigenetics. Epigenetics refers to changes in gene expression that are not due to alterations in the DNA sequence itself. miRNAs have been found to play important roles in epigenetic regulation, and dysregulation of miRNA-mediated epigenetic processes can contribute to cancer development and progression.

Overall, miRNA and Cancer, Volume 135 is an essential resource for researchers and students interested in the field of cancer research. The book provides comprehensive and up-to-date reviews on the role of miRNAs in cancer, covering a wide range of topics from biomarkers to animal models to epigenetics. The contributors to this volume are leading experts in the field, offering their insights and expertise to further our understanding of the complex relationship between miRNAs and cancer.

Whether you are a seasoned researcher or a student just starting out in the field, miRNA and Cancer, Volume 135 is a must-read. Its in-depth coverage of the latest research and its clear and concise writing style make it accessible to a wide range of readers. Order your copy today and embark on a journey into the fascinating world of miRNAs and cancer!