Brain tumors are a significant health concern, accounting for approximately 5-9% of all human neoplasms. In addition, central nervous system (CNS) tumors are among the most prevalent neoplasms in children. Understanding the molecular characteristics and pathways involved in tumorigenesis is crucial for determining the most effective treatment strategies. Furthermore, brain tumors possess mechanisms that allow them to evade the immune system’s attempts to eliminate them, leading to tumor development and progression. The field of neuro-immunology has shed light on the role of the immune system in both the development of brain tumors and the manifestation of psychiatric symptoms associated with these tumors. By targeting and activating the anti-tumor immune pathways, researchers have developed immunotherapeutic approaches to assist the weakened immune system in defeating brain tumors.

The first book of its kind, “Human Brain and Spinal Cord Tumors, Neuro-immunology and Neuro-genetics,” explores the neuro-immunology and neurogenetic pathways involved in the development of brain and spinal cord tumors. The book begins with an introduction to the field, followed by an in-depth exploration of the role of innate and acquired immunity in tumor development. It then delves into various immunotherapeutic approaches, such as Dendritic cell vaccination, DNA vaccines, peptide vaccines, viral vector-based vaccines, monoclonal antibodies, and CAR T-cell therapy, that aim to activate and strengthen the immune system’s ability to target and eliminate tumors. The book also examines the genetic aspects of brain and spinal cord tumors, including the involvement of specific genes and genetic pathways in tumorigenesis. Additionally, it explores bioinformatics models that can help predict the behavior of these tumors and inform therapeutic approaches, such as stem cell therapy and gene therapy.

This comprehensive volume is a valuable resource for experts in the fields of genetics, immunology, neurosurgery, neurology, neuropathology, and neuroradiology. It provides a deep dive into the complex interplay between the immune system, genetics, and tumor development, offering insights that can inform more targeted and effective treatment strategies. By understanding the molecular and immunological underpinnings of brain and spinal cord tumors, researchers and clinicians can develop innovative approaches to combat these neoplasms.

Published by Springer International Publishing, “Human Brain and Spinal Cord Tumors, Neuro-immunology and Neuro-genetics” is set to be released on January 1, 2023. The book is written in English and has the following ISBNs: 9783031147319 and 9783031147326.