Glioblastoma, Part II: Molecular Targets and Clinical Trials, An Issue of Neurosurgery Clinics of North America (Volume 32-2) (The Clinics: Surgery, Volume 32-2)

By Linda M. Liau MD PhD MBA
This issue of Neurosurgery Clinics, guest edited by Dr. Linda M. Liau, is dedicated to Glioblastoma: Molecular and Clinical Trials. This issue is one of four selected each year by the series consulting editors, Drs. Russell R. Lonser and Daniel K. Resnick. Topics will include―but are not limited to―Pathology & Molecular Markers, Cellular States & Genetic Diversity in Glioblastoma, Mismatch Repair in Glioblastoma Resistance, Genetic Susceptibility in Brain Cancer, Pediatric Gliomas: Molecular Landscape & Emerging Targets, Molecularly Targeted Clinical Trials, Novel Radiation Sensitizers, Immunotherapy Checkpoint Inhibitors, Brain Tumor Vaccines, CAR T Cells, Oncolytic Virotherapy, Targeting Cancer Stem Cells, Therapeutic Delivery to CNS, Theranostics: Dual Modality PET Tracers, and Neuroimaging & Novel Response Assessments.

The Glioblastoma: Molecular and Clinical Trials issue of Neurosurgery Clinics, edited by Dr. Linda M. Liau, is an essential resource for researchers and clinicians in the field of brain cancer. This issue covers a broad range of topics, including the molecular markers and genetic diversity of glioblastoma, new treatments such as immunotherapy and oncolytic virotherapy, and advanced neuroimaging techniques.

One of the most significant challenges in treating glioblastoma is its heterogeneity, the diversity of tumor cells that can differ in terms of their genetics, protein signaling, and metabolism. In the first article, Dr. Patrick Wen and Dr. Ryan Ungewickell discuss the state of the art in molecular profiling of glioblastoma, from DNA sequencing to single-cell transcriptomics. They also review recent studies that have identified potential therapeutic targets such as IDH1, EGFR, and PDGFRA.

Another challenging aspect of glioblastoma is its resistance to conventional treatments such as chemotherapy and radiation. Drs. Sophie Pautier and Frederic Dhermain discuss the role of the mismatch repair system in glioblastoma resistance and suggest new strategies such as PARP inhibitors and immune checkpoint blockade.

Recent advances in immunotherapy have shown promise in treating different types of cancer, including brain tumors. Drs. Michael Prados and David Reardon provide an overview of the different immunotherapy strategies that are being tested, including checkpoint inhibitors, CAR T cells, and brain tumor vaccines. They also review the results of recent clinical trials, highlighting the challenges and potential benefits of these approaches.

In addition to discussing new treatments, the issue also covers exciting developments in imaging techniques and response assessment. Drs. Joanna Jen and Whitney Pope describe the latest advances in neuroimaging, such as PET imaging with dual modality tracers and MRI-based perfusion techniques. They also discuss new response criteria that combine imaging and clinical data, such as the RANO criteria.

Overall, the Glioblastoma: Molecular and Clinical Trials issue of Neurosurgery Clinics is a must-read for anyone interested in brain cancer research and treatment. The collection of articles covers the most current and promising developments in the field, from molecular profiling and targeted therapies to immunotherapy and advanced neuroimaging.

If you’re a researcher or clinician working in the field of brain cancer, this issue is an indispensable reference that will help you stay up-to-date on the latest discoveries and trends. And if you’re a student or layperson interested in brain cancer, the issue provides an excellent introduction to the current state of research and treatment.

Anyone who orders this book will have access to a valuable resource that will help them understand the complex world of glioblastoma and stay current on the latest trends and breakthroughs. Whether you’re a clinician looking for new treatments, a researcher interested in molecular profiling, or a student seeking an introduction to brain cancer, this issue of Neurosurgery Clinics is an essential resource that you won’t want to miss.

Product Details

• Publisher ‏ : ‎ Elsevier (May 3, 2021)
• Language ‏ : ‎ English
• Hardcover ‏ : ‎ 240 pages
• ISBN-10 ‏ : ‎ 0323813054
• ISBN-13 ‏ : ‎ 978-0323813051