By Kasem Kulkeaw

This book presents an in-depth exploration of the disease model for malaria, a prevalent global public health issue. Malaria is a mosquito-borne infectious disease that affects millions of people worldwide, particularly in tropical and subtropical regions. Understanding the biology and mechanisms of malaria is crucial in developing effective strategies for prevention, treatment, and eradication of this devastating disease. In this book, the author Kasem Kulkeaw delves into the significance and advancements of the disease model for malaria, shedding light on the latest research and developments in the field.

One of the key highlights of the book is its comprehensive coverage of the malaria biology in the liver. The liver stage of malaria is a crucial phase in the life cycle of the malaria parasite, as it undergoes significant development and replication within the liver cells. The author provides detailed insights into the principles, protocols, and applications of in vitro platforms for studying liver-stage malaria. These platforms, such as liver organoids and liver-on-a-chip models, offer valuable tools for disease modeling and drug screening.

The initial chapter lays the foundation by discussing the role of stem cells in liver generation during development and in adults. Stem cells play a vital role in the regeneration and maintenance of liver tissue, and understanding their behavior is essential in modeling liver-stage malaria. The subsequent chapters delve into the recent advances in liver organoid and liver-on-a-chip technologies for studying malaria. The book includes protocols and methods for generating and utilizing these 3D models, highlighting their advantages and limitations.

Furthermore, the book explores the humanized mouse model of liver-stage malaria using ectopic artificial livers, which provides novel insights into the disease. The author also discusses the integration of biosensors with liver-on-a-chip technology, opening up new possibilities for assessing hepatocyte development viability and functions. The book emphasizes the potential of these advanced models to unravel the intricate cellular and molecular mechanisms underlying Plasmodium development in the liver, ultimately aiding in drug discovery.

Throughout the book, Kasem Kulkeaw expertly combines scientific knowledge with practical applications. The protocols, methods, and tools presented in this book are invaluable resources for researchers and scientists in various fields, including parasitology, cell biology, tissue engineering, and pharmacology.

Product Details

• Publisher: Springer; 1st ed. 2023 edition (May 30, 2023)
• Language: English
• eBook Digital: 105 pages
• ISBN-10: 9819906903
• ISBN-13: 978-9819906901

Order Now and Dive into the Fascinating World of Liver-Stage Malaria

If you are a researcher or scientist eager to expand your understanding of malaria biology and its implications for drug discovery, this book is an essential addition to your library. Kasem Kulkeaw guides you through the intricacies of liver-stage malaria, providing you with the necessary knowledge and tools to delve into this complex field of study.

By ordering this book, you gain access to a wealth of information on the disease model for malaria. You will learn about the latest advancements in liver organoid and liver-on-a-chip technologies, as well as the challenges and future directions in the field. From stem cell biology to biosensor integration, this book covers it all, equipping you with the necessary expertise to make significant contributions to the fight against malaria.

Now is the time to immerse yourself in the fascinating world of liver-stage malaria. Order this book today and embark on a journey of discovery and innovation in the field of parasitology, cell biology, tissue engineering, and pharmacology.