By Ranbir Chander Sobti, Sunil K. Lal, Ramesh K. Goyal

​This book presents drug repurposing strategies to combat infectious diseases and cancer. It discusses key experimental and in silico approaches for modern drug repositioning, including signature matching, molecular docking, genome-wide associated studies, and network-based approaches aided by artificial intelligence. Further, the book presents various computational and experimental strategies for better understanding disease mechanisms and identify repurposed drug candidates for personalized pharmacotherapy. It also explores the databases for drug repositioning, summarizes the approaches taken for drug repositioning, and highlights and compares their characteristics and challenges. Towards the end, the book discusses challenges and limitations encountered in computational drug repositioning.

Drug repurposing, also known as drug repositioning, is a process that involves finding new uses for existing drugs. This approach has gained significant attention in recent years due to its potential in quickly identifying new treatment options for various diseases. In the book “Drug Repurposing: Strategies for Fighting Infectious Diseases and Cancer,” authors Ranbir Chander Sobti, Sunil K. Lal, and Ramesh K. Goyal delve into the world of drug repurposing and explore the innovative strategies and techniques used in this field.

The book begins with an introduction to the concept of drug repurposing and its significance in combating infectious diseases and cancer. It discusses the limitations of traditional drug discovery methods and highlights the need for an alternative approach that can accelerate the drug development process. The authors then dive into various experimental and in silico approaches employed in modern drug repositioning.

One of the key techniques discussed in the book is signature matching. This method involves comparing the gene expression patterns of diseases with those of existing drugs to identify potential candidates for repurposing. The authors also explore molecular docking, which involves predicting the binding affinity between a drug and its target protein. This technique is particularly useful in identifying drugs that can effectively interact with disease-related proteins.

In addition to experimental approaches, the book also covers the role of computational methods in drug repurposing. Genome-wide association studies (GWAS) and network-based approaches aided by artificial intelligence are discussed in detail. GWAS helps in identifying potential associations between genetic variations and drug responses, while network-based approaches utilize the complex interactions within biological networks to uncover new drug targets.

Throughout the book, the authors provide insights into the challenges and limitations encountered in drug repurposing. They discuss the issues related to data availability, validation of candidate drugs, and regulatory considerations. By addressing these challenges, the book aims to provide a comprehensive understanding of the field and equip researchers with the necessary tools to overcome these obstacles.

Moreover, the book explores various databases and platforms available for drug repositioning. It highlights the strengths and limitations of each database and provides practical guidance on how to effectively utilize these resources in drug repurposing studies. The authors also summarize the approaches taken for drug repositioning and compare their characteristics, enabling readers to choose the most suitable method based on their specific research needs.

The book is written in a clear and concise manner, making it accessible to researchers, students, and professionals in the field of drug discovery. The authors provide numerous case studies and examples to illustrate the application of different strategies in drug repurposing. This practical approach enhances the readers’ understanding of the concepts discussed and enables them to apply these techniques in their own research.

Overall, “Drug Repurposing: Strategies for Fighting Infectious Diseases and Cancer” is a valuable resource for anyone interested in the field of drug repurposing. The book not only presents the latest strategies and techniques but also promotes a deeper understanding of disease mechanisms and the importance of personalized pharmacotherapy. With its comprehensive coverage and practical insights, this book is a must-have for researchers and professionals working in the field of drug discovery and development.

If you are eager to stay ahead in the field of drug repurposing and want to explore innovative strategies and techniques, “Drug Repurposing: Strategies for Fighting Infectious Diseases and Cancer” is the book for you. Order your copy today and unlock the potential of drug repurposing in combating infectious diseases and cancer.

Product Details

• Publisher ‏ : ‎ Springer; 1st ed. 2023 edition (February 8, 2023)
• Language ‏ : ‎ English
• eBook Digital ‏ : ‎ 675 pages
• ISBN-10 ‏ : ‎ 9811953988
• ISBN-13 ‏ : ‎ 978-9811953989