By Vinood B. Patel, Victor R. Preedy, Rajkumar Rajendram

This handbook of the series Biomarkers in Disease provides a comprehensive guide to monitoring and detecting toxicity in the human body and model organisms. With a focus on biomarkers for assessing toxicity in various organs, this book explores different assays and methods for detecting toxic substances. It also highlights the toxicity of single compounds and drugs for humans and describes the methods used to detect and measure toxicity.

Written by experts in the field, each chapter in this handbook presents key facts and definitions of important terms to facilitate understanding. It is an essential resource for researchers in toxicology and biomedicine who study the effects of drugs and other substances on the human body and model organisms. Additionally, it serves as a comprehensive guide for clinicians and pharmacologists.

Monitoring and Detecting Toxicity

One of the most critical challenges in toxicology and biomedicine is the ability to accurately monitor and detect toxicity in the human body. Toxicity refers to the adverse effects caused by exposure to toxic substances such as chemicals, drugs, or environmental pollutants. Timely detection of toxicity is crucial for early intervention and the prevention of further harm.

This handbook delves into the various biomarkers used to assess toxicity in different organs. Biomarkers are measurable indicators that can indicate the presence or extent of a disease or a toxic effect. By analyzing specific biomarkers, scientists and clinicians can gain insight into the toxicity of substances and make informed decisions regarding patient care or drug development.

Assays and Methods for Detecting Toxicity

The handbook covers a wide range of assays and methods used to detect and measure toxicity. These include biochemical assays, molecular analyses, imaging techniques, and animal models. Each method offers unique advantages and limitations in detecting and quantifying toxic effects.

For example, biochemical assays involve analyzing the levels of specific molecules or enzymes in blood or tissue samples. Molecular analyses focus on genetic or epigenetic changes associated with toxicity. Imaging techniques, such as MRI or PET scans, can provide visual evidence of organ damage or abnormalities. Animal models, including mice or zebrafish, can be used to study toxic effects in a controlled environment.

Understanding Toxicity of Single Compounds and Drugs

The handbook provides valuable insights into the toxicity of single compounds and drugs for humans. Each chapter discusses the specific toxic effects of different substances, including pharmaceutical drugs, environmental pollutants, and industrial chemicals. Understanding the toxicity profile of these compounds is crucial in assessing their safety and determining appropriate dosage levels.

The authors also describe the methods used to detect and measure the toxicity of these compounds. These methods include in vitro studies using cell lines, animal studies, and clinical trials. By understanding the toxic effects of these substances, researchers can develop strategies to minimize risks and optimize therapeutic interventions.

Benefits of the Handbook

With its comprehensive coverage of biomarkers, assays, and methods for detecting toxicity, this handbook is an invaluable resource for researchers, clinicians, and pharmacologists. It offers a thorough understanding of the latest advancements in toxicology research, providing insights into the mechanisms of toxic effects and potential strategies for intervention.

By reading this handbook, researchers can gain a deeper understanding of the complex relationship between toxic substances and the human body. Clinicians and pharmacologists can use this knowledge to make informed decisions regarding patient care and drug development. By staying updated on the latest research and techniques, professionals can provide the best possible outcomes for patients.

Order your copy of this handbook today and explore the fascinating world of toxicity monitoring and detection. With its comprehensive coverage and expert insights, this book is an essential addition to every researcher’s and professional’s library.

Product Details:

• Publisher: Springer; 1st ed. 2023 edition (February 1, 2023)
• Language: English
• eBook Digital: 1194 pages
• ISBN-10: 3031073916
• ISBN-13: 978-3031073915