Mutation-specific therapies in cystic fibrosis, 2nd Edition

Please log in to view the price.

Format : Publisher PDF

File Size : 3.4 MB

Category: RESPIRATORY BOOKS

Description

Mutation-specific therapies in cystic fibrosis, 2nd Edition

Cystic fibrosis is a severe ion channel disease of autosomal recessive inheritance that is caused by mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene. Thanks to continuously improved symptomatic treatment during the last five decades this lethal paediatric disease has been transformed into a chronic disorder with a median life expectancy of nowadays more than 50 years. This 2nd edition provides the reader with the background and on-going preclinical and clinical research for the development of mutation-type specific therapy of cystic fibrosis. Starting with the biology and biomarkers of CFTR in the context of cystic fibrosis, the reader gets insight into the basic and clinical research of CFTR modulators from bench to bedside. A large section of the book focuses on the clinical trials, post-approval observational studies and the real-world experience with the CFTR modulators. Cystic fibrosis is a severe ion channel disease of autosomal recessive inheritance that is caused by mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene. Thanks to continuously improved symptomatic treatment during the last five decades this lethal paediatric disease has been transformed into a chronic disorder with a median life expectancy of nowadays more than 50 years. This 2nd edition provides the reader with the background and on-going preclinical and clinical research for the development of mutation-type specific therapy of cystic fibrosis. Starting with the biology and biomarkers of CFTR in the context of cystic fibrosis, the reader gets insight into the basic and clinical research of CFTR modulators from bench to bedside. A large section of the book focuses on the clinical trials, post-approval observational studies and the real-world experience with the CFTR modulators.

Cystic Fibrosis: From Bench to Bedside, 2nd Edition is a comprehensive guide that delves into the biology, biomarkers, and current research surrounding the treatment of cystic fibrosis. Cystic fibrosis is a severe genetic disorder that affects the ion channels in the body, leading to a host of symptoms and complications. However, thanks to advancements in treatment over the past few decades, the life expectancy for those with cystic fibrosis has significantly increased, offering hope for a longer and healthier life.

The book begins by providing a detailed understanding of the biology and biomarkers of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene in the context of cystic fibrosis. It explores the role of CFTR modulators in the treatment of the disease, taking the reader through the journey of research and development from lab to clinical trials.

One of the standout features of this book is its focus on the real-world experience with CFTR modulators. The author shares insights gained from clinical trials, post-approval observational studies, and the experiences of patients who have undergone CFTR modulator therapy. This practical approach provides valuable information for both healthcare professionals and individuals affected by cystic fibrosis.

Whether you are a researcher, healthcare professional, or someone directly impacted by cystic fibrosis, this book offers a wealth of information that can help you understand the latest advancements in the treatment of this disease. It highlights the progress made in developing mutation-type specific therapies and sheds light on the future of cystic fibrosis treatment.

What sets this 2nd edition apart is the inclusion of up-to-date research and clinical findings. The field of cystic fibrosis is rapidly evolving, and this book ensures that readers have access to the most current information available. The inclusion of the latest research helps to bridge the gap between bench research and its practical application in the clinic.

The book is written in a way that is accessible to both scientific and non-scientific readers. The author breaks down complex concepts into easy-to-understand language, making it suitable for a wide range of audiences. The clear and concise explanations help to demystify the science behind cystic fibrosis, allowing readers to grasp the underlying mechanisms and appreciate the importance of CFTR modulators in treatment.

For those considering ordering the book, it is worth noting that it offers much more than a simple overview of cystic fibrosis. It provides a comprehensive exploration of the disease, from its molecular basis to the latest treatment options. The inclusion of real-world experiences further enhances the reader’s understanding and provides a sense of hope for individuals affected by cystic fibrosis.

In conclusion, Cystic Fibrosis: From Bench to Bedside, 2nd Edition is an invaluable resource for anyone interested in the treatment of cystic fibrosis. Its comprehensive coverage, up-to-date research, and practical insights make it a must-read for researchers, healthcare professionals, and individuals affected by the disease. Order your copy today and gain a deeper understanding of the biology, treatment, and future prospects for cystic fibrosis.