By Kasem Kulkeaw

This book, titled “Advances in Disease Modeling for Malaria: Liver Stage,” sheds light on the importance and advancements of the disease model for malaria, a significant global public health problem. Malaria, caused by the Plasmodium parasite, affects millions of people worldwide, leading to severe illness and even death. Understanding the biology of the disease in the liver stage is crucial for developing effective therapies and preventive measures.

Author Kasem Kulkeaw provides comprehensive information on the malaria biology in the liver and various in vitro platforms used for studying the liver stage of the disease. The book covers the principles, protocols, applications, and limitations of these platforms, offering researchers valuable insights and tools to advance their understanding of malaria.

The first chapter of the book sets the foundation by discussing the role of stem cells in liver generation during development and in adults. Subsequent chapters explore recent and emerging advances in liver organoid and liver-on-a-chip technologies for modeling malaria. These 3D models mimic the complexity of the liver, allowing researchers to study parasite development and behavior more accurately.

The book presents current protocols and methods for generating liver organoids and liver-on-a-chip models, highlighting their advantages and limitations. It also delves into the humanized mouse model of liver-stage malaria using ectopic artificial livers and introduces novel readout modalities for assessing hepatocyte development and functions. Additionally, it discusses the integration of liver-on-a-chip technology with biosensors to evaluate cell viability and functions, further advancing the field of disease modeling.

One of the key strengths of this book is its focus on the practical applications of the liver models in drug discovery. It provides researchers with the necessary tools and methodologies to investigate the efficacy of various drug candidates in combating malaria. Through these advancements, researchers can gain a deeper understanding of the cellular and molecular mechanisms involved in Plasmodium development in the liver, potentially leading to the development of more effective antimalarial drugs.

Overall, “Advances in Disease Modeling for Malaria: Liver Stage” serves as a comprehensive guide for researchers and scientists in the field of parasitology, cell biology, tissue engineering, and pharmacology. It offers valuable insights into the complexities of malaria in the liver stage and provides practical solutions for studying and combating the disease.

With a total of 105 pages, this book is published by Springer and is available in English. The first edition is set to be released on May 30, 2023. The ISBN-10 for the eBook version is 9819906903, and the ISBN-13 is 978-9819906901.

Order your copy of “Advances in Disease Modeling for Malaria: Liver Stage” today and embark on a journey to explore the intricate biology of malaria and contribute to the development of innovative solutions to combat this global health challenge. This book is not only a valuable resource for researchers and scientists but also a potential game-changer in the fight against malaria. Don’t miss out on the opportunity to deepen your knowledge and make a difference.

Note: For a more engaging and in-depth understanding, consider checking out relevant videos and supplementary materials recommended by the author alongside the book. These additional resources can provide visual demonstrations and further enrich your learning experience.