Non-coding Rna Transcripts in Cancer Therapy: Pre-clinical and Clinical Implications
By Gautam Sethi
‘Non-coding RNA Transcripts in Cancer Therapy: Pre-clinical and Clinical Implications’ provides a new insight towards role of non-coding RNAs molecules including microRNAs, long non-coding RNAs and circular RNAs in cancer. The reason of focusing on cancer is that this malignant disease is responsible for high death around the world and after cardiovascular diseases, it is a leading cause of death. In the current book, the basic information and knowledge about ncRNAs, their biogenesis and their biological functions are covered. It is shown that ncRNAs can regulate expression level of genes at transcriptional and post-transcriptional levels and therefore, ncRNAs are master and key players in molecular pathways. Then, the impact of regulation of molecular pathways by ncRNAs on important molecular mechanisms such as proliferation, metastasis, epithelial-to-mesenchymal transition, apoptosis and autophagy are described. All of these aspects are integrated in cancer and for treatment of this disease. In case of miRNAs, their biogenesis and biological functions in physiological conditions are described. Then, impact of miRNAs on proliferation, metastasis, therapy response (drug resistance and radio-resistance) is described. For lncRNAs and circRNAs, a same way is followed and their biogenesis and functional roles in cells are discussed. At the next step, function of lncRNAs and circRNAs in regulating proliferation, metastasis and therapy response (chemoresistance and radio-resistance) is introduced. These subjects are discussed based on pre-clinical studies and in order to make the book more comprehensive and broaden its scope, the function of exosomal ncRNAs in diagnosis and prognosis of cancer patients is described.
By Gautam Sethi
‘Non-coding RNA Transcripts in Cancer Therapy: Pre-clinical and Clinical Implications’ is a groundbreaking book that delves into the role of non-coding RNA molecules in cancer and its potential implications for therapy. Authored by renowned researcher Gautam Sethi, this book offers a comprehensive insight into the world of non-coding RNAs, including microRNAs, long non-coding RNAs, and circular RNAs, and their potential impact on the treatment of cancer.
Cancer remains one of the leading causes of death worldwide, and understanding the underlying molecular mechanisms behind this devastating disease is crucial for developing effective therapies. This book takes a deep dive into the world of non-coding RNAs and their intricate involvement in the complex molecular pathways of cancer.
The book begins by providing essential information and knowledge about non-coding RNAs, including their biogenesis and biological functions. Non-coding RNAs have emerged as key players in the regulation of gene expression at both the transcriptional and post-transcriptional levels, making them central to various molecular pathways. By exploring the impact of non-coding RNA regulation on crucial mechanisms such as proliferation, metastasis, epithelial-to-mesenchymal transition, apoptosis, and autophagy, the book highlights their potential role in cancer development and progression.
MicroRNAs, a prominent class of non-coding RNAs, are explored in detail. The book covers their biogenesis and biological functions in physiological conditions, shedding light on their role in maintaining cellular homeostasis. Additionally, the book investigates the impact of microRNAs on cancer-related processes such as proliferation, metastasis, and therapy response, including drug resistance and radio-resistance.
Long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) are also thoroughly examined in the book. Their biogenesis and functional roles within cells are discussed, offering valuable insights into their potential involvement in cancer. The book further explores the function of lncRNAs and circRNAs in regulating proliferation, metastasis, and therapy response, including chemoresistance and radio-resistance.
Adding to its comprehensiveness, the book also delves into the role of exosomal non-coding RNAs in the diagnosis and prognosis of cancer patients. Exosomes, which are extracellular vesicles released by cells, have gained significant attention as potential biomarkers for cancer. By exploring the function of exosomal non-coding RNAs in cancer diagnosis and prognosis, the book expands its scope and offers valuable information for researchers and clinicians.
‘Non-coding RNA Transcripts in Cancer Therapy: Pre-clinical and Clinical Implications’ is a vital resource for researchers, clinicians, and students interested in understanding the intricate world of non-coding RNA molecules and their potential applications in cancer therapy. Gautam Sethi’s expertise in the field ensures that readers gain valuable insights into the latest advancements and discoveries in this rapidly evolving area of research.
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If you are passionate about cancer research or interested in exploring the potential therapeutic implications of non-coding RNA molecules, ‘Non-coding RNA Transcripts in Cancer Therapy: Pre-clinical and Clinical Implications’ is a must-read. This comprehensive book offers in-depth knowledge, cutting-edge research, and valuable insights that can shape the future of cancer therapy.
Don’t miss out on the opportunity to enhance your understanding of this fascinating field. Order your copy of ‘Non-coding RNA Transcripts in Cancer Therapy’ today and embark on a journey into the world of non-coding RNAs and their potential role in revolutionizing cancer treatment.
Product Details
- Publisher : World Scientific Pub Co Inc (April 25, 2023)
- Language : English
- Hardcover : 376 pages
- ISBN-10 : 9811267383
- ISBN-13 : 978-9811267383