by Li Di (Editor), Edward H. Kerns (Editor)

Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant – and most challenging – areas of drug discovery.

In the world of pharmaceutical research, finding drugs that can effectively target the central nervous system (CNS) is a complex and challenging task. The blood-brain barrier (BBB), a protective barrier that separates the blood vessels of the brain from the rest of the body, presents a major obstacle in the development of CNS drugs. Understanding how the BBB works and finding ways to overcome its limitations is crucial for researchers in order to improve drug delivery to the brain and minimize side effects.

“Central Nervous System Drug Delivery: From Principles to Practice” is a comprehensive and informative book that dives deep into the world of CNS drug discovery and provides practical solutions for researchers. Edited by Li Di and Edward H. Kerns, two world experts in the field, this book brings together the latest research and strategies in understanding and overcoming the challenges of drug delivery to the CNS.

One of the key strengths of this book is its focus on practical solutions. It not only covers the theoretical concepts and current understanding of the BBB and CNS drug delivery, but also provides in silico, in vitro, and in vivo tools that can be used to assess brain penetration. The book also explores advanced drug delivery strategies that can enhance brain penetration and minimize CNS side effects.

The authors delve into the physiology of the BBB, explaining its structure and function in detail. They also discuss medicinal chemistry design principles and the free drug hypothesis for the BBB. Understanding these fundamental principles is crucial for researchers to design drugs that can efficiently cross the BBB and reach their target in the CNS.

In addition to covering the basic concepts, the book also discusses the latest developments in CNS drug delivery. It highlights the advances in modelling BBB pharmacokinetics and dynamics relationships (PK/PD) and physiologically-based pharmacokinetics (PBPK), providing researchers with valuable insights into predicting drug behavior in the brain.

“Central Nervous System Drug Delivery: From Principles to Practice” is not just a theoretical guide; it also includes case studies of successful CNS and non-CNS drugs. These case studies provide real-world examples of drugs that have successfully reached the market and the lessons learned from their development. By examining these examples, researchers can gain a better understanding of the practical challenges and opportunities in CNS drug discovery.

For anyone involved in CNS drug discovery, whether researchers, pharmacologists, or students, this book is an invaluable resource. It provides a comprehensive overview of the current state-of-the-art in CNS drug delivery and equips researchers with the knowledge and tools to make important advancements in this crucial field.

Order your copy of “Central Nervous System Drug Delivery: From Principles to Practice” today and join the ranks of researchers pushing the boundaries of CNS drug discovery.