Receptor Tyrosine Kinases in Neurodegenerative and Psychiatric Disorders

By Heba Mohamed Mansour, Mahmoud Mohamed Khattab, Aiman Saad El-Khatib

Receptor Tyrosine Kinases in Neurodegenerative and Psychiatric Disorders is a comprehensive guide providing a pragmatic map of RTKs structure, its activation, functions, mechanism of action, gene regulation, and signaling pathways in the developing central nervous system (CNS), adult normal CNS, neurodegenerative and psychiatric disorders. This incredible book is written by three international experts in the field, Heba Mohamed Mansour, Mahmoud Mohamed Khattab, and Aiman Saad El-Khatib.

The book focuses primarily on how the overexpression of receptor tyrosine kinases (RTKs) has been implicated in cancer and how a dysregulation of RTKs is reported in many neurodegenerative and psychiatric disorders. It highlights the importance of targeting RTKs and protein kinases for therapeutic approaches in various neurodegenerative and psychiatric disorders. The authors go into great detail and provide a thorough overview of RTKs biology, RTK families, the numerous receptors within each subfamily, and their role in health and disease progression and modulation.

One key feature of this book is that it provides a comprehensive discussion of results of pre-clinical and clinical studies of repositioning of anti-cancer receptor tyrosine kinase inhibitors (RTKIs) and other promising protein kinase inhibitors in various neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, Huntington’s disease, and multiple sclerosis, and psychiatric disorders, including anxiety, depression, alcohol use disorder, and schizophrenia.

The book offers an excellent opportunity to explore the obstacles and opportunities for the potential repositioning of kinase inhibitors in neurodegenerative and psychiatric disorders. This aspect makes the book stand out as a valuable resource for researchers, clinicians, and students alike.

Another significant aspect of this book is the expertise of the contributors from different fields such as biology, pharmacology, neurology, psychiatry, and oncology. Their contributions provide great insights into the latest research on RTKs in neurodegenerative and psychiatric disorders.

Receptor Tyrosine Kinases in Neurodegenerative and Psychiatric Disorders also discusses the future directions of possible safe effective targeted RTKIs and other protein kinase inhibitors that may be repositioned in various neurodegenerative and psychiatric disorders. This aspect of the book presents the excitement of the latest research in the field and how it may translate into new therapeutic approaches for these devastating diseases.

In terms of the book’s structure, it is well-organized and easy to read. Chapters flow smoothly from one topic to the next, providing clear explanations of complex information. The book’s language is straightforward and uncomplicated, making it accessible to both experts and novices in the field.

Moreover, the book includes how prospective treatments should be evolved with the advancement of technology to provide beneficence. It highlights the future of targeted therapeutics by focusing on molecularly effective, low-toxicity, and disease-modifying agents that work by improving the fundamental signaling pathways present in these disorders.

Overall, Receptor Tyrosine Kinases in Neurodegenerative and Psychiatric Disorders is a valuable resource for any researcher or clinician interested in the latest research on RTKs and their potential therapeutic approaches in neurodegenerative and psychiatric disorders. The book is an essential addition to any library and should be a must-read for anyone interested in these fields.

In conclusion, if you are someone who is passionate about the latest developments in neurodegenerative and psychiatric disorders, this book is a must-read for you. You will not only learn about the latest research in the field, but it will also provide you with new insights into how we can target RTKs for therapeutic approaches in treating these diseases. Without hesitation, I would recommend you to order this book right away and see how it can benefit your knowledge and practice in the field.

Product Details

• Provides a thorough overview of RTKs biology and their role in health and disease progression and modulation
• Highlights RTK families and the numerous receptors within each subfamily
• Examines RTKIs and other protein kinase inhibitors in pre-clinical and clinical trials in both neurodegenerative and psychiatric disorders
• Gives future directions of possible safe effective targeted RTKIs and other protein kinase inhibitors that may be repositioned in various neurodegenerative and psychiatric disorders
• Includes chapter contributions from renowned experts in biology, pharmacology, neurology, psychiatry, and oncology

• Publisher ‏ : ‎ Academic Press; 1st edition (June 22, 2023)
• Language ‏ : ‎ English
• ‏ : ‎ 604 pages
• ISBN-10 ‏ : ‎ 0443186774
• ISBN-13 ‏ : ‎ 978-0443186776